SAMHD1

Across TCGA patient cohorts, SAMHD1 mutation is significantly associated with the RNA expression of many other genes, with 3,435 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAMHD1-associated genes across cancer lineages are ERH, ICMT, and ACP1. Each is linked with SAMHD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SAMHD1-to-partner and partner-to-SAMHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERH grouped by SAMHD1-low versus SAMHD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMHD1→partner) and Y-score (partner→SAMHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERH →	+0.275	+3.627	.007	.001	3	3
UCEC	ICMT →	+0.522	+4.233	<.001	<.001	3	3
UCEC	ACP1 →	+0.430	+2.263	<.001	<.001	3	3
BLCA	MIR3908 →	+0.357	+5.411	<.001	.005	3	3
UCEC	C12orf43 →	+0.275	+2.273	.001	<.001	3	3
UCEC	CSRP2 →	+0.801	+2.098	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,435 associations by consensus.

ERH by SAMHD1 expression — UCEC

Explore this box plot interactively →