SAMHD1

Across TCGA patient cohorts, SAMHD1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAMHD1-associated genes across cancer lineages are FASN, FoxM1, and INPP4B. Each is linked with SAMHD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAMHD1-to-partner and partner-to-SAMHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by SAMHD1-low versus SAMHD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMHD1→partner) and Y-score (partner→SAMHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.346	+2.999	.017	.035	3	2
UCEC	FoxM1 →	+0.329	+3.392	<.001	<.001	3	2
UCEC	INPP4B →	-0.258	-1.678	.029	.021	3	2
UCEC	JNK2 →	+0.256	+2.486	<.001	.009	3	2
UCEC	mTOR_pS2448 →	-0.124	-1.986	.023	.029	3	2
UCEC	Notch1 →	+0.175	+2.247	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

FASN by SAMHD1 expression — UCEC

Explore this box plot interactively →