SAMHD1

Across TCGA cell cohorts, SAMHD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,798 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible SAMHD1-associated GO terms across cancer lineages are Deoxyribonucleoside triphosphate metabolic process, Deoxyribonucleotide catabolic process, and Purine nucleoside triphosphate catabolic process. Each is linked with SAMHD1 in more than 17 cancer types. Because this analysis shows association rather than direction, both SAMHD1-to-partner and partner-to-SAMHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Deoxyribonucleoside triphosphate metabolic process grouped by SAMHD1-low versus SAMHD1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMHD1→partner) and Y-score (partner→SAMHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Deoxyribonucleoside triphosphate metabolic process →	+0.157	+2.145	<.001	<.001	3	17
KIDNEY	Deoxyribonucleotide catabolic process →	+0.234	+1.682	<.001	.003	2	18
URINARY_TRACT	Purine nucleoside triphosphate catabolic process →	+0.145	+1.771	<.001	<.001	3	16
URINARY_TRACT	Deoxyribonucleoside triphosphate catabolic process →	+0.145	+1.771	<.001	<.001	3	16
URINARY_TRACT	Purine deoxyribonucleoside triphosphate metabolic process →	+0.148	+1.771	<.001	<.001	3	16
BREAST	Purine deoxyribonucleoside triphosphate catabolic process →	+0.165	+1.639	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,798 associations by consensus.

Deoxyribonucleoside triphosphate metabolic process by SAMHD1 expression — URINARY_TRACT

Explore this box plot interactively →