Across TCGA patient cohorts, SAMD9 mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAMD9-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and mTOR_pS2448. Each is linked with SAMD9 in more than 3 cancer types. Because this analysis shows association rather than direction, both SAMD9-to-partner and partner-to-SAMD9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD9→partner) and Y-score (partner→SAMD9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.327	+1.321	<.001	.010	3	4
LUAD	Caspase-7-cleavedD198 →	+0.472	+2.132	.011	.010	2	4
UCEC	mTOR_pS2448 →	-0.084	-1.164	.031	.019	3	3
UCEC	p27_pT198 →	+0.063	+1.280	.023	.003	3	3
LUAD	EGFR_pY1068 →	-0.410	-2.459	.040	.018	3	2
LUAD	FoxM1 →	+0.315	+3.033	.003	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

Exploration

SAMD9 survival (RNA) · tumor vs normal (RNA) · all SAMD9 data types