SAMD8

Across TCGA pan-cancer cohorts, SAMD8 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SAMD8 data layer compared with 25 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SAMD8 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SAMD8 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC and UCEC are the cancer types where SAMD8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.078	0.695	<.001	18	view →
UCEC	DFS	Median	All	1.000	0.637	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SAMD8–HNSC (DFS)

Open the HNSC breakdown →