SAMD8

Across TCGA patient cohorts, SAMD8 mutation is significantly associated with the RNA expression of many other genes, with 1,029 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAMD8-associated genes across cancer lineages are ZBTB45P2, IGHD3-16, and RNU6ATAC30P. Each is linked with SAMD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAMD8-to-partner and partner-to-SAMD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZBTB45P2 grouped by SAMD8-low versus SAMD8-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD8→partner) and Y-score (partner→SAMD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	ZBTB45P2 →	+0.060	+3.891	<.001	.008	3	2
UCEC	IGHD3-16 →	+1.111	+2.458	<.001	<.001	3	2
UCEC	RNU6ATAC30P →	+0.344	+2.154	<.001	.004	3	2
UCEC	IGHD1-1 →	+0.554	+3.220	<.001	.005	3	2
UCEC	RNU6-718P →	+0.163	+3.761	<.001	.001	3	2
COAD	MIR378E →	+0.813	+5.136	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,029 associations by consensus.

ZBTB45P2 by SAMD8 expression — LUSC

Explore this box plot interactively →