SAMD8

Across TCGA patient cohorts, SAMD8 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAMD8-associated genes across cancer lineages are VHL, 14-3-3_beta, and JNK_pT183_Y185. Each is linked with SAMD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAMD8-to-partner and partner-to-SAMD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by SAMD8-low versus SAMD8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD8→partner) and Y-score (partner→SAMD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.622	-2.459	.042	.019	3	2
UCEC	14-3-3_beta →	-0.109	-2.973	.016	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.201	-2.321	.008	.034	3	1
UCEC	MEK1 →	+0.529	+2.700	.001	.006	2	2
UCEC	Notch1 →	+0.161	+2.179	.011	.034	3	1
UCEC	Akt_pS473 →	+0.731	+2.321	.023	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

VHL by SAMD8 expression — UCEC

Explore this box plot interactively →