SAMD8

Across TCGA cell cohorts, SAMD8 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,818 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SAMD8-associated GO terms across cancer lineages are Regulation of hippo signaling, Sphingomyelin biosynthetic process, and Macroautophagy. Each is linked with SAMD8 in more than 15 cancer types. Because this analysis shows association rather than direction, both SAMD8-to-partner and partner-to-SAMD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of hippo signaling grouped by SAMD8-low versus SAMD8-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD8→partner) and Y-score (partner→SAMD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of hippo signaling →	+0.098	+0.885	<.001	<.001	3	16
STOMACH	Sphingomyelin biosynthetic process →	+0.123	+1.039	.002	<.001	3	14
BONE	Macroautophagy →	+0.056	+0.591	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Negative regulation of hippo signaling →	+0.101	+0.685	<.001	<.001	3	14
BLOOD_Lymphoma	Protein localization to chromosome, telomeric region →	+0.092	+0.774	<.001	<.001	3	14
BLOOD_Lymphoma	Peptidyl-serine modification →	+0.075	+0.945	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,818 associations by consensus.

Regulation of hippo signaling by SAMD8 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →