SAMD8

Across TCGA cell cohorts, SAMD8 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SAMD8-associated genes across cancer lineages are PPP1R2C, OR9K2, and REC114. Each is linked with SAMD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAMD8-to-partner and partner-to-SAMD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP1R2C grouped by SAMD8-low versus SAMD8-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD8→partner) and Y-score (partner→SAMD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PPP1R2C →	+0.240	+4.539	<.001	.007	3	1
BLOOD_Leukemia	OR9K2 →	+0.021	+4.539	<.001	.007	3	1
BLOOD_Leukemia	REC114 →	+0.179	+4.409	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

PPP1R2C by SAMD8 expression — BLOOD_Leukemia

Explore this box plot interactively →