Across TCGA pan-cancer cohorts, SAMD5 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SAMD5 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SAMD5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SAMD5 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ACC, SARC, and UCEC are the cancer types where SAMD5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.113	0.822	<.001	21	view →
SARC	OS	Median	All	0.144	0.745	.001	6	view →
UCEC	DFS	Median	All	1.000	0.831	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: SAMD5 tumor-vs-normal RNA expression · all SAMD5 data types