Across TCGA patient cohorts, SAMD5 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAMD5-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and A-Raf_pS299. Each is linked with SAMD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAMD5-to-partner and partner-to-SAMD5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD5→partner) and Y-score (partner→SAMD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.293	-3.584	.007	.002	3	1
UCEC	eIF4E →	+0.216	+2.807	.019	.003	3	1
UCEC	A-Raf_pS299 →	-0.137	-2.115	.008	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.201	-2.321	.006	.034	3	1
UCEC	JNK2 →	+0.234	+2.115	.006	.019	3	1
UCEC	Ku80 →	+0.234	+1.598	.023	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Exploration

SAMD5 survival (RNA) · tumor vs normal (RNA) · all SAMD5 data types