SAMD3

Across TCGA patient cohorts, SAMD3 mutation is significantly associated with the RNA expression of many other genes, with 3,832 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAMD3-associated genes across cancer lineages are RNA5SP73, BRWD1P2, and AKR1A1. Each is linked with SAMD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SAMD3-to-partner and partner-to-SAMD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP73 grouped by SAMD3-low versus SAMD3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD3→partner) and Y-score (partner→SAMD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP73 →	+0.363	+5.252	<.001	.002	3	3
CESC	BRWD1P2 →	+0.265	+4.234	.004	.003	3	3
UCEC	AKR1A1 →	+0.280	+2.545	.002	<.001	3	3
HNSC	RNU6-1305P →	+0.202	+4.327	<.001	.009	3	3
BLCA	RN7SKP272 →	+0.328	+4.304	.002	.001	3	3
SCLC	FANCD2OS →	+0.071	+3.847	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,832 associations by consensus.

RNA5SP73 by SAMD3 expression — CESC

Explore this box plot interactively →