SAMD3

Across TCGA patient cohorts, SAMD3 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAMD3-associated genes across cancer lineages are MEK1, PCNA, and Shc_pY317. Each is linked with SAMD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAMD3-to-partner and partner-to-SAMD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SAMD3-low versus SAMD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD3→partner) and Y-score (partner→SAMD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.366	+2.070	.001	.001	3	2
UCEC	PCNA →	+0.134	+1.415	.048	.043	3	2
UCEC	Shc_pY317 →	-0.123	-2.000	.009	.029	3	2
UCEC	ATM →	-0.335	-1.794	.018	.024	3	2
UCEC	Di-Ras3 →	-0.099	-1.502	.033	.027	3	2
UCEC	14-3-3_beta →	-0.067	-1.124	.034	.041	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

MEK1 by SAMD3 expression — UCEC

Explore this box plot interactively →