SAMD3

Across TCGA cell cohorts, SAMD3 mutation is significantly associated with the mutation status of many other genes, with 1,738 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SAMD3-associated genes across cancer lineages are TAS1R3, ARID4A, and NACA. Each is linked with SAMD3 in more than 3 cancer types. Because this analysis shows association rather than direction, both SAMD3-to-partner and partner-to-SAMD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAS1R3 grouped by SAMD3-low versus SAMD3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD3→partner) and Y-score (partner→SAMD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TAS1R3 →	+4.014	+4.969	.008	.008	1	4
SKIN	ARID4A →	+3.133	+3.000	.003	.003	1	4
SOFT_TISSUE	NACA →	+5.066	+4.502	.007	.007	1	4
BREAST	SMARCA2 →	+3.169	+2.974	.003	.003	1	3
BLOOD_Lymphoma	LAMB1 →	+4.014	+4.969	.008	.008	1	3
LARGE_INTESTINE	HSF5 →	+3.087	+4.392	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,738 associations by consensus.

TAS1R3 by SAMD3 expression — BLOOD_Lymphoma

Explore this box plot interactively →