SAMD14

Across TCGA patient cohorts, SAMD14 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAMD14-associated genes across cancer lineages are ERK2, EGFR_pY1068, and eIF4E. Each is linked with SAMD14 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAMD14-to-partner and partner-to-SAMD14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by SAMD14-low versus SAMD14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD14→partner) and Y-score (partner→SAMD14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.239	+2.999	.013	.035	3	2
UCEC	EGFR_pY1068 →	-0.308	-2.321	.014	.035	2	2
UCEC	eIF4E →	+0.240	+2.321	.023	.035	2	2
UCEC	Ku80 →	+0.245	+2.335	.039	.020	3	1
UCEC	PCNA →	+0.269	+3.169	.013	.019	3	1
UCEC	PDK1_pS241 →	+0.219	+3.321	.010	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

ERK2 by SAMD14 expression — UCEC

Explore this box plot interactively →