SAMD14

Across TCGA cell cohorts, SAMD14 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SAMD14-associated genes across cancer lineages are NPVF, GLYATL3, and KLF18. Each is linked with SAMD14 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAMD14-to-partner and partner-to-SAMD14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPVF grouped by SAMD14-low versus SAMD14-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD14→partner) and Y-score (partner→SAMD14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	NPVF →	+0.020	+5.000	<.001	.005	3	1
KIDNEY	GLYATL3 →	+0.043	+5.000	<.001	.005	3	1
KIDNEY	KLF18 →	+0.006	+5.000	<.001	.005	3	1
LARGE_INTESTINE	OR10Q1 →	+0.101	+3.920	.003	.005	3	1
LARGE_INTESTINE	OR52B6 →	+0.081	+3.920	<.001	.005	3	1
BLOOD_Leukemia	MAGEB4 →	+0.046	+4.705	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

NPVF by SAMD14 expression — KIDNEY

Explore this box plot interactively →