SAMD12

Across TCGA patient cohorts, SAMD12 mutation is significantly associated with the RNA expression of many other genes, with 607 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SAMD12-associated genes across cancer lineages are KIT, RNU7-29P, and COX6CP12. Each is linked with SAMD12 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAMD12-to-partner and partner-to-SAMD12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIT grouped by SAMD12-low versus SAMD12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD12→partner) and Y-score (partner→SAMD12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KIT →	-0.894	-4.087	.001	<.001	3	2
BRCA	RNU7-29P →	+1.312	+8.055	<.001	.007	3	2
SKCM	COX6CP12 →	+0.053	+2.398	<.001	.001	3	2
LUAD	LCEP1 →	+0.079	+7.930	<.001	.008	3	2
UCEC	SLC24A3 →	-0.877	-3.438	.001	.005	3	2
UCEC	RNA5SP86 →	+0.351	+2.492	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 607 associations by consensus.

KIT by SAMD12 expression — UCEC

Explore this box plot interactively →