SAMD12

Across TCGA patient cohorts, SAMD12 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SAMD12-associated genes across cancer lineages are PEA-15_pS116, eEF2, and JNK_pT183_Y185. Each is linked with SAMD12 in more than 2 cancer types. Because this analysis shows association rather than direction, both SAMD12-to-partner and partner-to-SAMD12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PEA-15_pS116 grouped by SAMD12-low versus SAMD12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD12→partner) and Y-score (partner→SAMD12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PEA-15_pS116 →	+0.470	+3.169	.014	.020	3	3
SKCM	eEF2 →	+0.395	+3.186	.004	.009	3	2
SKCM	JNK_pT183_Y185 →	-0.140	-3.321	.014	.009	3	2
SKCM	ER-alpha →	-0.183	-2.446	.019	.018	3	1
SKCM	FOXO3a →	-0.099	-1.700	.042	.043	3	1
SKCM	NF2 →	+0.240	+3.321	.029	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

PEA-15_pS116 by SAMD12 expression — UCEC

Explore this box plot interactively →