SAMD1

Across TCGA pan-cancer cohorts, SAMD1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SAMD1 data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher SAMD1 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated SAMD1 expression acts as an unfavorable survival marker, although some lineages such as SCLC show a favorable association.

SCLC and PRAD are the cancer types where SAMD1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	IV	0.719	0.167	.035	9	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SAMD1–SCLC (OS)

Open the SCLC breakdown →