SAMD1

Across TCGA pan-cancer cohorts, SAMD1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SAMD1 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SAMD1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SAMD1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

HNSC, LSCC, and CCRCC are the cancer types where SAMD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.666	0.910	<.001	59	view →
LSCC	OS	Median	All	0.896	0.748	.009	19	view →
CCRCC	DFS	Tertile	III,IV	0.714	0.383	.015	12	view →
COAD	DFS	Median	All	1.000	0.936	.047	6	view →
PDAC	DFS	Median	IV	0.741	0.214	.017	6	view →
GBM	OS	Tertile	All	0.526	0.308	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SAMD1–HNSC (DFS)

Open the HNSC breakdown →