SALL2

Across TCGA pan-cancer cohorts, SALL2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SALL2 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SALL2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SALL2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC, UCEC, and GBM are the cancer types where SALL2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	III,IV	1.000	0.480	.002	41	view →
UCEC	OS	Tertile	All	0.886	1.000	.016	24	view →
GBM	DFS	Tertile	All	0.530	0.272	.008	10	view →
PDAC	OS	Median	II,III,IV	0.748	0.508	.031	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SALL2–LSCC (DFS)

Open the LSCC breakdown →