SALL2

Across TCGA patient cohorts, SALL2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SALL2-associated genes across cancer lineages are PCNA, FOXO3a, and Heregulin. Each is linked with SALL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SALL2-to-partner and partner-to-SALL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SALL2-low versus SALL2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SALL2→partner) and Y-score (partner→SALL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.274	+3.012	.010	.018	3	3
SKCM	FOXO3a →	-0.092	-1.874	.046	.047	3	3
COAD	Heregulin →	-0.134	-2.416	.047	.020	3	2
COAD	ASNS →	+0.575	+2.467	<.001	.011	3	2
UCEC	PR →	-0.186	-1.584	.024	.034	3	2
UCEC	AR →	-0.296	-1.874	.016	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

PCNA by SALL2 expression — COAD

Explore this box plot interactively →