SALL2

Across TCGA cell cohorts, SALL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,914 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SALL2-associated GO terms across cancer lineages are RNA splicing, via transesterification reactions with bulged adenosine as nucleophile, mRNA splicing, via spliceosome, and Heterochromatin formation. Each is linked with SALL2 in more than 18 cancer types. Because this analysis shows association rather than direction, both SALL2-to-partner and partner-to-SALL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA splicing, via transesterification reactions with bulged adenosine as nucleophile grouped by SALL2-low versus SALL2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SALL2→partner) and Y-score (partner→SALL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.080	+2.928	<.001	<.001	3	19
BONE	mRNA splicing, via spliceosome →	+0.080	+2.928	<.001	<.001	3	19
STOMACH	Heterochromatin formation →	+0.085	+2.334	<.001	<.001	3	18
STOMACH	Epigenetic regulation of gene expression →	+0.079	+2.050	<.001	.003	3	18
STOMACH	Negative regulation of gene expression, epigenetic →	+0.084	+2.327	<.001	<.001	3	18
BONE	RNA splicing, via transesterification reactions →	+0.079	+2.479	<.001	.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,914 associations by consensus.

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile by SALL2 expression — BONE

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