SALL2

Across TCGA cell cohorts, SALL2 mutation is significantly associated with the RNA expression of many other genes, with 120 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SALL2-associated genes across cancer lineages are DPRX, NPHS2, and OR5AK2. Each is linked with SALL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SALL2-to-partner and partner-to-SALL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPRX grouped by SALL2-low versus SALL2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SALL2→partner) and Y-score (partner→SALL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DPRX →	+0.060	+5.954	<.001	<.001	3	2
URINARY_TRACT	NPHS2 →	+0.187	+5.044	<.001	<.001	3	2
BLOOD_Lymphoma	OR5AK2 →	+0.038	+4.662	<.001	.003	3	2
URINARY_TRACT	NOBOX →	+0.020	+5.044	<.001	<.001	3	1
URINARY_TRACT	CLEC14A →	+0.013	+4.217	.007	.005	3	1
URINARY_TRACT	TMEM252 →	+0.637	+4.217	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 120 associations by consensus.

DPRX by SALL2 expression — SOFT_TISSUE

Explore this box plot interactively →