SALL1

Across TCGA patient cohorts, SALL1 mutation is significantly associated with the RNA expression of many other genes, with 7,241 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SALL1-associated genes across cancer lineages are FAXDC2, NDC80, and SDK1. Each is linked with SALL1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SALL1-to-partner and partner-to-SALL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAXDC2 grouped by SALL1-low versus SALL1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SALL1→partner) and Y-score (partner→SALL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FAXDC2 →	-0.833	-2.070	<.001	.001	3	5
LUAD	NDC80 →	+0.615	+1.284	<.001	.005	3	5
LUSC	SDK1 →	-0.653	-1.999	.003	.008	3	4
LUSC	CD1A →	-0.622	-1.807	.006	.004	3	4
STAD	MS4A4E →	-0.322	-2.584	.004	<.001	3	4
LUAD	CENPA →	+0.550	+1.284	.006	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,241 associations by consensus.

FAXDC2 by SALL1 expression — LUAD

Explore this box plot interactively →