Q-omics provides the consensus-scored SAGE2P profile across patient tissues and cancer cell-line models. SAGE2P expression is associated with patient survival in 11 of 34 cancer types, with the highest sampling consensus in LUAD. Additionally, SAGE2P RNA expression shows 4,410 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight LUAD, and STAD as cancer lineages where SAGE2P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

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Survival associations

This table summarizes SAGE2P survival associations across molecular data types. SAGE2P RNA expression shows survival associations in the most cancer types (11). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

SAGE2P data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	11	LUAD (54)	view →

This table ranks reproducible SAGE2P RNA expression–survival associations across cancer types. High SAGE2P expression shows unfavorable associations in LUAD, ACC, TGCT and MESO, but favorable associations in UCS and HNSC. The LUAD Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LUAD as the clearest survival context for SAGE2P RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.109	0.750	<.001	54	view →
UCS	DFS	Tertile	II,III,IV	0.574	0.157	.005	48	view →
ACC	DFS	Tertile	All	0.084	0.634	.003	36	view →
TGCT	DFS	Tertile	II,III,IV	0.368	0.953	.001	36	view →
HNSC	OS	Tertile	III,IV	0.775	0.315	.019	36	view →
MESO	OS	Tertile	All	0.316	0.559	.020	27	view →

Pink = unfavorable, green = favorable. all 11 lineages →

SAGE2P-LUAD (OS)

Kaplan–Meier survival curve for SAGE2P RNA expression in LUAD: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with SAGE2P in patient tissues and cancer cell lines. In patient samples, SAGE2P shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
Function (RNA)	4,410	STAD (3785)	view →
RNA	3,855	COAD (1771)	view →