SAG

Across TCGA patient cohorts, SAG RNA expression is significantly associated with the go_rna of many other GO terms, with 6,943 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SAG-associated GO terms across cancer lineages are Oxidative phosphorylation, Ribose phosphate biosynthetic process, and Proton motive force-driven ATP synthesis. Each is linked with SAG in more than 18 cancer types. Because this analysis shows association rather than direction, both SAG-to-partner and partner-to-SAG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Oxidative phosphorylation grouped by SAG-low versus SAG-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SAG→partner) and Y-score (partner→SAG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Oxidative phosphorylation →	+0.085	+0.101	<.001	<.001	3	19
ESCA	Ribose phosphate biosynthetic process →	+0.087	+0.098	<.001	.001	3	17
STAD	Proton motive force-driven ATP synthesis →	+0.087	+0.094	<.001	<.001	3	17
STAD	Aerobic respiration →	+0.085	+0.107	<.001	<.001	3	17
ESCA	Nucleoside triphosphate biosynthetic process →	+0.094	+0.130	<.001	.006	3	17
ESCA	Regulation of double-strand break repair →	+0.095	+0.157	<.001	.002	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,943 associations by consensus.

Oxidative phosphorylation by SAG expression — STAD

Explore this box plot interactively →