SAG

Across TCGA cell cohorts, SAG RNA expression is significantly associated with the go_rna of many other GO terms, with 1,745 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SAG-associated GO terms across cancer lineages are G protein-coupled opsin signaling pathway, Negative regulation of circadian rhythm, and Urea transmembrane transport. Each is linked with SAG in more than 12 cancer types. Because this analysis shows association rather than direction, both SAG-to-partner and partner-to-SAG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, G protein-coupled opsin signaling pathway grouped by SAG-low versus SAG-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SAG→partner) and Y-score (partner→SAG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	G protein-coupled opsin signaling pathway →	+0.550	+1.444	.001	<.001	3	13
BONE	Negative regulation of circadian rhythm →	+0.137	+1.075	<.001	.001	3	5
BLOOD_Leukemia	Urea transmembrane transport →	-0.885	-0.259	<.001	.004	3	4
STOMACH	Regulation of ATPase-coupled calcium transmembrane transporter activity →	-0.161	-0.085	.001	.004	3	4
BONE	Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway →	+0.151	+1.097	<.001	<.001	3	4
BONE	Positive regulation of growth →	-0.069	-1.341	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,745 associations by consensus.

G protein-coupled opsin signaling pathway by SAG expression — BONE

Explore this box plot interactively →