SAG

Across TCGA cell cohorts, SAG mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SAG-associated genes across cancer lineages are CFHR2, MROH2B, and OR6C4. Each is linked with SAG in more than 1 cancer types. Because this analysis shows association rather than direction, both SAG-to-partner and partner-to-SAG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR2 grouped by SAG-low versus SAG-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAG→partner) and Y-score (partner→SAG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CFHR2 →	+0.038	+4.022	<.001	.006	3	1
LUNG_SCLC	MROH2B →	+0.016	+5.029	<.001	.006	3	1
LUNG_SCLC	OR6C4 →	+0.012	+5.029	.001	.006	3	1
LUNG_SCLC	PRAMEF6 →	+0.016	+5.029	<.001	.006	3	1
LUNG_SCLC	SPATS1 →	+0.170	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

CFHR2 by SAG expression — LARGE_INTESTINE

Explore this box plot interactively →