SAFB2

Across TCGA pan-cancer cohorts, SAFB2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SAFB2 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SAFB2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SAFB2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, HNSC, and PDAC are the cancer types where SAFB2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	III,IV	0.931	0.321	.010	19	view →
HNSC	DFS	Tertile	IV	0.499	0.810	.002	15	view →
PDAC	OS	Median	IV	0.951	0.381	.006	14	view →
COAD	DFS	Median	III,IV	1.000	0.898	.047	6	view →
GBM	OS	Quartile	All	0.669	0.291	.007	6	view →
CCRCC	OS	Median	III,IV	0.869	0.704	.041	3	view →
LSCC	OS	Quartile	II,III,IV	0.941	0.664	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SAFB2–LUAD (OS)

Open the LUAD breakdown →