SAFB2

Across TCGA cell cohorts, SAFB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,673 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SAFB2-associated GO terms across cancer lineages are Constitutive heterochromatin formation, Regulation of transcription of nucleolar large rRNA by RNA polymerase I, and Positive regulation of anaphase-promoting complex-dependent catabolic process. Each is linked with SAFB2 in more than 17 cancer types. Because this analysis shows association rather than direction, both SAFB2-to-partner and partner-to-SAFB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Constitutive heterochromatin formation grouped by SAFB2-low versus SAFB2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SAFB2→partner) and Y-score (partner→SAFB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Constitutive heterochromatin formation →	+0.110	+0.966	.004	.003	3	18
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.143	+1.000	<.001	<.001	3	18
LUNG_SCLC	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.184	+0.825	<.001	<.001	3	18
STOMACH	Subtelomeric heterochromatin formation →	+0.142	+0.851	<.001	<.001	3	18
BONE	Epigenetic regulation of gene expression →	+0.098	+1.291	<.001	<.001	3	18
BONE	Heterochromatin formation →	+0.094	+1.426	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,673 associations by consensus.

Constitutive heterochromatin formation by SAFB2 expression — BONE

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