SAFB2

Across TCGA cell cohorts, SAFB2 mutation is significantly associated with the RNA expression of many other genes, with 50 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SAFB2-associated genes across cancer lineages are MYOD1, HHLA1, and ST8SIA2. Each is linked with SAFB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAFB2-to-partner and partner-to-SAFB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYOD1 grouped by SAFB2-low versus SAFB2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAFB2→partner) and Y-score (partner→SAFB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYOD1 →	+0.012	+3.922	<.001	.002	3	1
BLOOD_Leukemia	HHLA1 →	+0.009	+3.966	<.001	.001	3	1
BLOOD_Leukemia	ST8SIA2 →	+0.796	+3.906	<.001	.003	3	1
BLOOD_Leukemia	MC2R →	+0.003	+3.969	<.001	.009	3	1
BLOOD_Leukemia	GUCA2A →	+0.026	+3.969	<.001	.009	3	1
BLOOD_Leukemia	DPRX →	+0.071	+3.475	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

MYOD1 by SAFB2 expression — BLOOD_Leukemia

Explore this box plot interactively →