SAFB

Across TCGA pan-cancer cohorts, SAFB mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SAFB data layer compared with 22 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SAFB mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SAFB expression acts as an unfavorable survival marker, although some lineages such as LUAD and COAD show a favorable association.

HNSC, LUAD, and COAD are the cancer types where SAFB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	0.516	0.873	.001	36	view →
LUAD	DFS	Median	All	0.968	0.866	.006	36	view →
COAD	DFS	Tertile	II,III,IV	1.000	0.827	.021	30	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	14	view →
LSCC	OS	Tertile	II,III,IV	0.901	0.644	.017	12	view →
GBM	OS	Quartile	All	0.585	0.320	.007	9	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SAFB–HNSC (DFS)

Open the HNSC breakdown →