SAE1

Across TCGA pan-cancer cohorts, SAE1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SAE1 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SAE1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SAE1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

HNSC, LSCC, and UCEC are the cancer types where SAE1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.416	0.985	.008	38	view →
LSCC	DFS	Tertile	III,IV	0.893	0.387	.013	16	view →
UCEC	DFS	Tertile	II,III,IV	0.529	0.926	.022	14	view →
GBM	OS	Tertile	All	0.602	0.255	.005	7	view →
LUAD	DFS	Median	All	0.948	0.673	.012	4	view →
CCRCC	DFS	Quartile	III,IV	0.881	0.435	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SAE1–HNSC (DFS)

Open the HNSC breakdown →