SAE1

Across TCGA patient cohorts, SAE1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAE1-associated genes across cancer lineages are IGFBP2, MEK1, and MYH11. Each is linked with SAE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAE1-to-partner and partner-to-SAE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by SAE1-low versus SAE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAE1→partner) and Y-score (partner→SAE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.878	-2.000	.002	.032	3	1
UCEC	MEK1 →	+0.472	+3.807	.004	<.001	3	1
UCEC	MYH11 →	+1.289	+2.700	.012	.006	3	1
UCEC	p62 Lck ligand →	+0.408	+3.469	.005	.002	3	1
UCEC	PKC-a →	+0.449	+2.820	.013	.035	3	1
UCEC	Annexin-1 →	+0.572	+3.189	.016	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

IGFBP2 by SAE1 expression — UCEC

Explore this box plot interactively →