SACS

Across TCGA pan-cancer cohorts, SACS Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated SACS data layer compared with 29 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SACS Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SACS expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

ACC, LUSC, and UCEC are the cancer types where SACS Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.010	0.667	<.001	45	view →
LUSC	OS	Median	All	0.215	0.822	.003	37	view →
UCEC	DFS	Median	All	0.820	0.608	<.001	36	view →
BRCA	OS	Median	IV	0.106	0.791	<.001	18	view →
SKCM	DFS	Median	All	0.842	0.717	.007	17	view →
KIRP	DFS	Median	II,III,IV	0.037	0.783	<.001	12	view →
LIHC	DFS	Median	All	0.933	0.530	.006	9	view →
COAD	OS	Median	III,IV	0.451	0.813	.001	8	view →
STAD	OS	Median	III,IV	0.869	0.403	.025	6	view →
SARC	DFS	Median	All	0.168	0.497	.037	3	view →
BLCA	DFS	Median	III,IV	0.169	0.497	.012	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

SACS–ACC (DFS)

Open the ACC breakdown →