SACS

Across TCGA pan-cancer cohorts, SACS mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SACS data layer compared with 29 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SACS mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SACS expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

CCRCC, PDAC, and OV are the cancer types where SACS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	0.632	0.933	.009	21	view →
PDAC	OS	Tertile	III,IV	0.255	0.868	.005	12	view →
OV	DFS	Median	All	0.818	1.000	.038	4	view →
LUAD	OS	Median	All	0.589	0.848	.030	2	view →
LSCC	OS	Tertile	All	0.978	0.851	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SACS–CCRCC (DFS)

Open the CCRCC breakdown →