SACS

Across TCGA patient cohorts, SACS protein abundance is significantly associated with the RNA expression of many other genes, with 5,190 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SACS-associated genes across cancer lineages are SACS-AS1, SGCG, and TREM1. Each is linked with SACS in more than 3 cancer types. Because this analysis shows association rather than direction, both SACS-to-partner and partner-to-SACS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SACS versus SACS-AS1 in UCEC, with a Pearson correlation of 0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SACS→partner) and Y-score (partner→SACS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SACS-AS1 →	+0.500	+0.376	<.001	<.001	3	4
GBM	SGCG →	+0.975	+0.535	<.001	<.001	3	4
OV	TREM1 →	+0.915	+0.561	.003	.001	3	3
UCEC	MFAP2 →	+1.177	+0.423	.001	.002	3	3
UCEC	TNFRSF19 →	+1.501	+0.392	<.001	.003	3	3
HNSC	DCLK1 →	+0.942	+0.298	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,190 associations by consensus.

SACS vs SACS-AS1 — UCEC

Explore this scatter interactively →