SACS

Across TCGA patient cohorts, SACS mutation is significantly associated with the total protein of many other genes, with 122 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SACS-associated genes across cancer lineages are ATM, PCNA, and 4E-BP1. Each is linked with SACS in more than 5 cancer types. Because this analysis shows association rather than direction, both SACS-to-partner and partner-to-SACS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SACS-low versus SACS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SACS→partner) and Y-score (partner→SACS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.413	-1.632	<.001	<.001	3	6
STAD	PCNA →	+0.249	+3.000	.004	<.001	3	5
LUAD	4E-BP1 →	+0.358	+1.887	.004	.029	3	5
UCEC	eIF4E →	+0.128	+1.584	.008	<.001	3	5
COAD	Caspase-7-cleavedD198 →	+0.804	+1.847	<.001	.007	3	5
STAD	GSK-3a-b_pS21_S9 →	-0.387	-1.874	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 122 associations by consensus.

ATM by SACS expression — UCEC

Explore this box plot interactively →