SACS

Across TCGA cell cohorts, SACS RNA expression is significantly associated with the go_rna of many other GO terms, with 5,414 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SACS-associated GO terms across cancer lineages are Regulation of mitotic sister chromatid separation, Mitotic spindle organization, and Regulation of chromosome segregation. Each is linked with SACS in more than 14 cancer types. Because this analysis shows association rather than direction, both SACS-to-partner and partner-to-SACS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mitotic sister chromatid separation grouped by SACS-low versus SACS-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SACS→partner) and Y-score (partner→SACS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of mitotic sister chromatid separation →	+0.119	+1.214	<.001	.004	3	15
STOMACH	Mitotic spindle organization →	+0.104	+2.174	<.001	<.001	3	15
BREAST	Regulation of chromosome segregation →	+0.109	+1.481	.001	.003	3	15
UPPER_AERODIGESTIVE_TRACT	Centrosome cycle →	+0.086	+1.265	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Microtubule organizing center organization →	+0.087	+1.222	<.001	<.001	3	14
SOFT_TISSUE	Microtubule polymerization or depolymerization →	+0.105	+0.964	<.001	.006	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,414 associations by consensus.

Regulation of mitotic sister chromatid separation by SACS expression — BREAST

Explore this box plot interactively →