SACS

Across TCGA cell cohorts, SACS mutation is significantly associated with the RNA expression of many other genes, with 1,263 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SACS-associated genes across cancer lineages are RTN3, NEMP1, and SLC38A9. Each is linked with SACS in more than 3 cancer types. Because this analysis shows association rather than direction, both SACS-to-partner and partner-to-SACS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RTN3 grouped by SACS-low versus SACS-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SACS→partner) and Y-score (partner→SACS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RTN3 →	+0.474	+3.380	.004	.001	3	3
BLOOD_Leukemia	NEMP1 →	+0.706	+2.115	.001	.008	3	3
BLOOD_Leukemia	SLC38A9 →	+0.470	+3.215	.004	.005	3	3
LUNG_NSCLC_LUAD	CHRNA5 →	+0.563	+2.376	.007	.009	2	4
OVARY	MYORG →	+1.073	+3.584	.003	<.001	3	3
LARGE_INTESTINE	DNAJC3 →	+0.435	+1.787	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,263 associations by consensus.

RTN3 by SACS expression — BLOOD_Leukemia

Explore this box plot interactively →