Across TCGA pan-cancer cohorts, SACM1L mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SACM1L data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher SACM1L mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SACM1L expression acts as an unfavorable survival marker, although some lineages such as HNSC and OV show a favorable association.

GBM, HNSC, and OV are the cancer types where SACM1L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Median	All	0.251	0.469	<.001	28	view →
HNSC	OS	Median	All	0.821	0.598	.005	21	view →
OV	DFS	Median	All	0.886	0.582	.028	4	view →
UCEC	DFS	Tertile	All	0.786	0.945	.036	4	view →
LUAD	DFS	Median	III,IV	0.581	0.902	.044	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SACM1L tumor-vs-normal RNA expression · all SACM1L data types