Across TCGA patient cohorts, SACM1L mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SACM1L-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and FASN. Each is linked with SACM1L in more than 1 cancer types. Because this analysis shows association rather than direction, both SACM1L-to-partner and partner-to-SACM1L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SACM1L→partner) and Y-score (partner→SACM1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.248	-1.678	.009	.023	3	1
UCEC	eIF4E →	+0.200	+2.584	.013	.001	2	2
UCEC	FASN →	+0.413	+2.000	.006	.030	3	1
UCEC	ACC1 →	+0.398	+1.750	.004	.049	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.605	+2.087	.001	.005	3	1
UCEC	NF-kB-p65_pS536 →	-0.349	-2.999	.045	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

SACM1L survival (RNA) · tumor vs normal (RNA) · all SACM1L data types