Across TCGA cell cohorts, SACM1L mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SACM1L-associated genes across cancer lineages are ADGRE3, ASGR2, and EIF4E1B. Each is linked with SACM1L in more than 1 cancer types. Because this analysis shows association rather than direction, both SACM1L-to-partner and partner-to-SACM1L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SACM1L→partner) and Y-score (partner→SACM1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ADGRE3 →	+0.027	+3.459	.002	.006	3	1
CNS	ASGR2 →	+0.114	+3.560	<.001	.008	3	1
CNS	EIF4E1B →	+0.050	+3.906	.005	.003	3	1
CNS	MAGEB10 →	+0.619	+4.300	<.001	.001	3	1
CNS	ZNF716 →	+0.550	+3.657	<.001	.006	3	1
CNS	CYP2A13 →	+0.021	+3.459	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

SACM1L survival (RNA) · tumor vs normal (RNA) · all SACM1L data types