SAAL1

Across TCGA patient cohorts, SAAL1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAAL1-associated genes across cancer lineages are C-Raf, eIF4E, and MEK1. Each is linked with SAAL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAAL1-to-partner and partner-to-SAAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by SAAL1-low versus SAAL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAAL1→partner) and Y-score (partner→SAAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.156	+1.906	.006	.016	3	2
UCEC	eIF4E →	+0.182	+2.820	.032	.035	3	1
UCEC	MEK1 →	+0.414	+2.807	.004	.003	3	1
UCEC	mTOR_pS2448 →	-0.143	-3.150	.017	.019	3	1
UCEC	Notch1 →	+0.173	+1.906	.002	.016	3	1
UCEC	p62 Lck ligand →	+0.344	+2.459	.008	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

C-Raf by SAAL1 expression — UCEC

Explore this box plot interactively →