SAA4

Across TCGA cell cohorts, SAA4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,754 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible SAA4-associated GO terms across cancer lineages are Complement-mediated synapse pruning, Negative regulation of immune response, and Skin epidermis development. Each is linked with SAA4 in more than 7 cancer types. Because this analysis shows association rather than direction, both SAA4-to-partner and partner-to-SAA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Complement-mediated synapse pruning grouped by SAA4-low versus SAA4-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SAA4→partner) and Y-score (partner→SAA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Complement-mediated synapse pruning →	+1.483	+0.530	<.001	.005	3	8
BREAST	Negative regulation of immune response →	+0.076	+0.588	<.001	.002	3	8
UPPER_AERODIGESTIVE_TRACT	Skin epidermis development →	+0.131	+1.755	<.001	<.001	3	8
BREAST	Positive regulation of complement activation →	+1.150	+0.575	.001	.001	3	7
URINARY_TRACT	Vertebrate eye-specific patterning →	+1.397	+0.544	<.001	.004	3	7
BREAST	T cell activation →	+0.052	+0.696	.002	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,754 associations by consensus.

Complement-mediated synapse pruning by SAA4 expression — URINARY_TRACT

Explore this box plot interactively →