SAA2

Across TCGA pan-cancer cohorts, SAA2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SAA2 data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SAA2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SAA2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, CCRCC, and GBM are the cancer types where SAA2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	0.878	0.385	<.001	46	view →
CCRCC	OS	Quartile	II,III,IV	0.643	0.968	.014	12	view →
GBM	DFS	Quartile	All	0.612	0.790	.015	5	view →
LUAD	DFS	Median	II,III,IV	0.811	0.456	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SAA2–HNSC (DFS)

Open the HNSC breakdown →