SAA2-SAA4

Across TCGA pan-cancer cohorts, SAA2-SAA4 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SAA2-SAA4 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SAA2-SAA4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SAA2-SAA4 expression acts as an unfavorable survival marker.

KIRP, HNSC, and COAD are the cancer types where SAA2-SAA4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	II,III,IV	0.127	0.859	<.001	48	view →
HNSC	OS	Median	All	0.198	0.769	<.001	33	view →
COAD	OS	Median	All	0.131	0.809	<.001	16	view →
LUSC	OS	Median	All	0.081	0.818	<.001	12	view →
SKCM	OS	Median	All	0.258	0.783	.012	12	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SAA2-SAA4–KIRP (OS)

Open the KIRP breakdown →