S1PR5

Across TCGA pan-cancer cohorts, S1PR5 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated S1PR5 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher S1PR5 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated S1PR5 expression acts as an unfavorable survival marker.

LIHC are the cancer types where S1PR5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.044	0.553	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

S1PR5–LIHC (DFS)

Open the LIHC breakdown →