S1PR5

Across TCGA patient cohorts, S1PR5 mutation is significantly associated with the RNA expression of many other genes, with 447 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible S1PR5-associated genes across cancer lineages are RN7SL756P, HMX3, and NPM1P9. Each is linked with S1PR5 in more than 1 cancer types. Because this analysis shows association rather than direction, both S1PR5-to-partner and partner-to-S1PR5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL756P grouped by S1PR5-low versus S1PR5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (S1PR5→partner) and Y-score (partner→S1PR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL756P →	+0.477	+3.695	<.001	.009	3	2
COAD	HMX3 →	+1.134	+3.734	<.001	.002	3	2
COAD	NPM1P9 →	+0.331	+3.362	.006	.005	3	2
UCEC	ZIC5 →	+1.569	+3.793	<.001	.001	3	2
UCEC	MIR7976 →	+0.588	+2.868	<.001	.006	3	2
BLCA	RPSAP57 →	+0.047	+4.973	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 447 associations by consensus.

RN7SL756P by S1PR5 expression — SKCM

Explore this box plot interactively →